Anti-Bacillus anthracis PA/pagA/PA-83 Antibody (SAA1376)

Description: Anti-Bacillus anthracis PA/pagA/PA-83 Antibody (SAA1376) [SAA1376] (RA11777) is a human monoclonal antibody detecting PA-83 in ELISA, SPR. Suitable for Bacillus anthracis.
Host species: Human
Isotype: IgG1, kappa
Species reactivity: Bacillus anthracis
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1.5 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, SPR
Target: Protective antigen, PA, Anthrax toxins translocating protein, PA-83, PA83, Protective antigen PA-20, PA-20, PA20, Protective antigen PA-63, PA-63, PA63, pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Protective antigen (PA/pagA) is a ~85 kDa protein. Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax.
References:
1. Bradley, KA. et al. (2001) Nature 414, 225-9. PMID: 11700562
2. Bradley, KA. et al. (2003) The Journal of biological chemistry 278, 49342-7. PMID: 14507921
3. Santelli, E. et al. (2004) Nature 430, 905-8. PMID: 15243628
4. Lacy, DB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 13147-51. PMID: 15326297
5. Singh, Y. et al. (1991) The Journal of biological chemistry 266, 15493-7. PMID: 1651334
6. Mock, M. et al. (2001) Annual review of microbiology 55, 647-71. PMID: 11544370
Note: For research use only.