Anti-Mouse MAPT/Tau/PHF-tau Antibody (TAU-5)

Description: Anti-Mouse MAPT/Tau/PHF-tau Antibody (TAU-5) [TAU-5] (RA11882) is a mouse monoclonal antibody detecting PHF-tau in IF, IHC-P, IP, WB. Suitable for Human, Mouse, Rat, Bovine, and Sheep.
Highlights:
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research.
Host species: Mouse
Isotype: IgG1, kappa
Species reactivity: Human, Mouse, Rat, Bovine, Sheep
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: IF, IHC-P, IP, WB
Target: MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Microtubule-associated protein tau (MAPT) is a ~76 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Note: For research use only.