Anti-MARV GP/Envelope glycoprotein Antibody (MR78)

Description: Anti-MARV GP/Envelope glycoprotein Antibody (MR78) [MR78] (RA11900) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA.
Host species: Human
Isotype: IgG1
Species reactivity: Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strainKenya/Ravn/1987))
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Envelope glycoprotein, GP1,2, GP, Virion spike glycoprotein, GP1, GP2, GP
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Envelope glycoprotein (GP) is a ~75 kDa protein. GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection).
Note: For research use only.