Anti-pan-MAGUK Antibody (K28/86)

Description: Anti-pan-MAGUK Antibody (K28/86) [K28/86] (RA11925) is a mouse monoclonal antibody detecting pan-MAGUK in IHC, IP, WB. Suitable for Human, Mouse, Rat, and Drosophila.
Highlights:
• Multi-Application — Validated across multiple applications.
• Multi-Species — Cross-reactive for translational research.
Host species: Mouse
Isotype: IgG1, kappa
Species reactivity: Human, Mouse, Rat, Drosophila
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: IHC, IP, WB
Target: PSD-95, PSD95, Disks large homolog 4, Synapse-associated protein 90, DLG4, Postsynaptic density protein 95, SAP-90, SAP90
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Disks large homolog 4 (Membrane-associated guanylate kinases (MAGUK)) is a ~80 kDa protein. Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly.
References:
1. Brigidi, GS. et al. (2015) Nature communications 6, 8200. PMID: 26334723
Note: For research use only.