Anti-Human FOS Antibody (N486/76)

Description: Anti-Human FOS Antibody (N486/76) [N486/76] (RA11948) is a mouse monoclonal antibody detecting FOS in IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights:
• Multi-Species — Cross-reactive for translational research.
Host species: Mouse
Isotype: IgG2a
Species reactivity: Human, Mouse, Rat
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: IHC, WB
Target: FOS, G0S7, Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Protein c-Fos is a ~40 kDa protein. Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Note: For research use only.