InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

Description: InVivoMAb Anti-Mouse IL17A Antibody (BZN035) [BZN035] (RA11959) is a mouse monoclonal antibody detecting CTLA-8 in FCM, Neutralization. Suitable for Mouse.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications.
Host species: Mouse
Isotype: IgG2a
Species reactivity: Mouse
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 3.3 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: FCM, Neutralization
Target: CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx).
References:
1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225
2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317
3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948
4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068
5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633
6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703
Note: For research use only. Not suitable for clinical or therapeutic use.