InVivoMAb Anti-JUNV GP1 glycoprotein Antibody (JUN1#)

Description: InVivoMAb Anti-JUNV GP1 glycoprotein Antibody (JUN1#) [JUN1#] (RA11981) is a human monoclonal antibody detecting Pre-glycoprotein polyprotein GP complex in ELISA, Neutralization.
Host species: Human
Isotype: IgG1, kappa
Species reactivity: Junin mammarenavirus (JUNV) (Junn mammarenavirus)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: Pre-glycoprotein polyprotein GP complex, Pre-GP-C, Stable signal peptide, SSP, Glycoprotein G1, GP1, Glycoprotein G2, GP2, GPC
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Pre-glycoprotein polyprotein GP complex (GP1 glycoprotein) is a ~55 kDa protein. Functions as a cleaved signal peptide that is retained as the third component of the GP complex (GP-C). Helps to stabilize the spike complex in its native conformation. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of G1 and G2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.
References:
1. York, J. et al. (2004) Journal of virology 78, 10783-92. PMID: 15367645
2. York, J. et al. (2006) Journal of virology 80, 7775-80. PMID: 16840359
Note: For research use only. Not suitable for clinical or therapeutic use.