InVivoMAb Anti-Human SNCA Antibody (Iv0173)

Description: InVivoMAb Anti-Human SNCA Antibody (Iv0173) [Iv0173] (RA12030) is a mouse monoclonal antibody detecting Alpha-synuclein in ELISA, Neutralization. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging.
References:
1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282
2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 2644259
3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128
4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
Note: For research use only. Not suitable for clinical or therapeutic use.