Anti-Human Histone H3 trimethyl Lys27 (H3K27me3) Antibody (2E12#)

Description: Anti-Human Histone H3 trimethyl Lys27 (H3K27me3) Antibody (2E12#) [2E12#] (RA12071) is a mouse monoclonal antibody detecting Histone H3/j in ELISA, IF, IP, DB. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG1
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Histone H3/j, Histone H3/b, Histone H3/d, Histone H3/c, HIST1H3B, H3FH, Histone H3/f, H3FF, H3FK, HIST1H3G, H3FL, H3FB, HIST1H3D, Histone H3/a, H3FI, Histone H3/i, H3FD, HIST1H3A, Histone H3/h, HIST1H3I, HIST1H3E, HIST1H3H, HIST1H3J, H3C1, H3FC HIST1H3C, H3FA, Histone H3.1, H3FJ, Histone H3/l, Histone H3/k, HIST1H3F
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Histone H3.1 (Histone H3 trimethyl Lys27 (H3K27me3)) is a ~15 kDa protein. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Note: For research use only.