Anti-Human ARTN/Artemin Antibody (A10)

Description: Anti-Human ARTN/Artemin Antibody (A10) [A10] (RA12075) is a mouse monoclonal antibody detecting Artemin in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: EVN, Artemin, Enovin, ARTN, Neublastin
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Artemin (ARTN) is a ~22 kDa protein. Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
References:
1. Masure, S. et al. (1999) European journal of biochemistry 266, 892-902. PMID: 10583383
2. Baloh, RH. et al. (1998) Neuron 21, 1291-302. PMID: 9883723
3. Li, J. et al. (2019) eLife 8. PMID: 31535977
Note: For research use only.