InVivoMAb Anti-HSV1/HHV1 gB/Envelope glycoprotein B (Fd79)

Description: InVivoMAb Anti-HSV1/HHV1 gB/Envelope glycoprotein B (Fd79) [Fd79] (RA12086) is a human monoclonal antibody detecting Envelope glycoprotein B in Blocking, ELISA, FCM.
Highlights:
• Multi-Application — Validated across multiple applications.
• Flow Cytometry — Validated for flow cytometry applications.
Host species: Human
Isotype: IgG1
Species reactivity: Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Blocking, ELISA, FCM
Target: Envelope glycoprotein B, gB, UL27
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Envelope glycoprotein B (gB) is a ~100 kDa protein. Envelope glycoprotein that forms spikes at the surface of virion envelope and binds to the host cell entry receptors MYH9/NMMHC-IIA and MYH10/NMMHC-IIB, promoting the virus entry into host cells. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell: following initial binding to its host cell entry receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).
Note: For research use only. Not suitable for clinical or therapeutic use.