InVivoMAb Anti-Human PAUF Antibody (Iv0188)

Description: InVivoMAb Anti-Human PAUF Antibody (Iv0188) [Iv0188] (RA12089) is a human monoclonal antibody detecting Pancreatic adenocarcinoma upregulated factor in Blocking, ELISA. Suitable for Human.
Host species: Human
Isotype: IgG1, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Blocking, ELISA
Target: Pancreatic adenocarcinoma upregulated factor, PAUF
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Pancreatic adenocarcinoma up-regulated factor (PAUF) is a ~18 kDa protein. Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Contributes to maintain homeostasis in the oral microbiome by capturing commensal microbes and regulating their growth using a mucin-assisted clearance mechanism. Plays an important role in pancreatic tumor progression and metastasis. Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kappaB signaling pathway, without the involvement of the TLR4/TRIF pathway.
References:
1. Ghosh, S. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2216304120. PMID: 37216558
2. Kim, SA. et al. (2009) Cancer science 100, 828-36. PMID: 19302292
3. Youn, SE. et al. (2022) International journal of molecular sciences 23. PMID: 36232715
Note: For research use only. Not suitable for clinical or therapeutic use.