Anti-Human RAMP3 Antibody (SAA1504)

Description: Anti-Human RAMP3 Antibody (SAA1504) [SAA1504] (RA12148) is a mouse monoclonal antibody detecting RAMP3 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, RAMP3, CRLR activity-modifying protein 3
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Receptor activity-modifying protein 3 (RAMP3) is a ~16 kDa protein. Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP.
References:
1. Lenhart, PM. et al. (2013) Journal of molecular endocrinology 51, 191-202. PMID: 23674134
2. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
3. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767
4. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283
Note: For research use only.