Anti-Human KRAS/K-Ras 2 Antibody (SAA1513)

Description: Anti-Human KRAS/K-Ras 2 Antibody (SAA1513) [SAA1513] (RA12157) is a mouse monoclonal antibody detecting K-Ras 2 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: c-Ki-ras, RASK2, GTPase KRas, K-Ras 2, c-K-ras, KRAS, Ki-Ras, KRAS2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: GTPase KRas (K-Ras 2) is a ~21 kDa protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
References:
1. Gremer, L. et al. (2011) Human mutation 32, 33-43. PMID: 20949621
2. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765
3. Yang, MH. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10843-8. PMID: 22711838
4. Zimmermann, G. et al. (2013) Nature 497, 638-42. PMID: 23698361
5. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306
Note: For research use only.