Anti-Human CD5L Antibody (SAA1515)

Description: Anti-Human CD5L Antibody (SAA1515) [SAA1515] (RA12159) is a mouse monoclonal antibody detecting CD5L in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, IgM-associated peptide, CT-2, hAIM, API6, SP-alpha, CD5L
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: CD5 antigen-like (CD5L) is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).
References:
1. Amézaga, N. et al. (2014) Journal of leukocyte biology 95, 509-20. PMID: 24295828
2. Sarrias, MR. et al. (2005) The Journal of biological chemistry 280, 35391-8. PMID: 16030018
3. Sanjurjo, L. et al. (2013) PloS one 8, e79670. PMID: 24223991
4. Martinez, VG. et al. (2014) Cellular & molecular immunology 11, 343-54. PMID: 24583716
5. Sanjurjo, L. et al. (2015) Autophagy 11, 487-502. PMID: 25713983
6. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878
Note: For research use only.