Anti-Human SCN2B Antibody (SAA1523)

Description: Anti-Human SCN2B Antibody (SAA1523) [SAA1523] (RA12167) is a mouse monoclonal antibody detecting SCN2B in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: SCN2B, Sodium channel subunit beta-2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels.
References:
1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477
2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163
3. Das, S. et al. (2016) eLife 5. PMID: 26894959
4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605
5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606
6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491
7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201
Note: For research use only.