Anti-Human LRP5 Antibody (SAA1526)

Description: Anti-Human LRP5 Antibody (SAA1526) [SAA1526] (RA12170) is a mouse monoclonal antibody detecting LRP5 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs.
References:
1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703
2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771
3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191
4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503
5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424
6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235
Note: For research use only.