Anti-Human PGLYRP1 Antibody (SAA1529)

Description: Anti-Human PGLYRP1 Antibody (SAA1529) [SAA1529] (RA12173) is a mouse monoclonal antibody detecting PGLYRP1 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Peptidoglycan recognition protein 1, PGLYRP, PGRP, Peptidoglycan recognition protein short, TNFSF3L, PGRP-S, PGLYRP1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Peptidoglycan recognition protein 1 (PGLYRP1) is a ~21 kDa protein. Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system.
References:
1. Kang, D. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 10078-82. PMID: 9707603
2. Yashin, DV. et al. (2011) The Journal of biological chemistry 286, 10258-64. PMID: 21247889
3. Yashin, DV. et al. (2015) The Journal of biological chemistry 290, 21724-31. PMID: 26183779
4. Dukhanina, EA. et al. (2015) Cell cycle (Georgetown, Tex.) 14, 3635-43. PMID: 26654597
5. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 3071377
6. Sharapova, TN. et al. (2017) Journal of innate immunity 9, 598-608. PMID: 28977785
7. Sharapova, TN. et al. (2017) IUBMB life 69, 971-977. PMID: 29083508
8. Read, CB. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1417-21. PMID: 25595774
Note: For research use only.