Anti-Human S100B Antibody (SAA1555)

Description: Anti-Human S100B Antibody (SAA1555) [SAA1555] (RA12199) is a mouse monoclonal antibody detecting S100B in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: S100 calcium-binding protein B, S100B, S-100 protein subunit beta, Protein S100-B, S-100 protein beta chain
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Protein S100-B (S100B) is a ~10 kDa protein. Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation. Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue.
References:
1. Ostendorp, T. et al. (2011) Biochimica et biophysica acta 1813, 1083-91. PMID: 20950652
2. Baudier, J. et al. (1984) Biochimica et biophysica acta 790, 164-73. PMID: 6487634
3. Gilquin, B. et al. (2010) Molecular and cellular biology 30, 2724-36. PMID: 20351179
4. Yamaguchi, F. et al. (2012) The Journal of biological chemistry 287, 13787-98. PMID: 22399290
Note: For research use only.