Anti-Human HLA-C Antibody (SAA1568)

Description: Anti-Human HLA-C Antibody (SAA1568) [SAA1568] (RA12212) is a mouse monoclonal antibody detecting HLA-C in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: HLA-Cw, HLA-C, Human leukocyte antigen C, HLAC, HLA class I histocompatibility antigen, C alpha chain
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: HLA class I histocompatibility antigen, C alpha chain (HLA-C) is a ~40 kDa protein. Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth. During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells. Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection.
References:
1. Addo, MM. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 1781-6. PMID: 11172028
2. Makadzange, AT. et al. (2010) European journal of immunology 40, 1036-41. PMID: 20104487
3. Fadda, L. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 10160-5. PMID: 20439706
4. Hiby, SE. et al. (2010) The Journal of clinical investigation 120, 4102-10. PMID: 20972337
5. Xiong, S. et al. (2013) The Journal of clinical investigation 123, 4264-72. PMID: 24091323
6. Kaur, G. et al. (2017) Nature communications 8, 15924. PMID: 28649982
7. Hosie, L. et al. (2017) Frontiers in immunology 8, 1776. PMID: 29312307
8. Stewart, CA. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 13224-9. PMID: 16141329
Note: For research use only.