Anti-Human TSPAN8 Antibody (SAA1592)

Description: Anti-Human TSPAN8 Antibody (SAA1592) [SAA1592] (RA12236) is a mouse monoclonal antibody detecting TSPAN8 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: TSPAN8, Tspan-8, Tumor-associated antigen CO-029, TM4SF3, Transmembrane 4 superfamily member 3, Tetraspanin-8
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Tetraspanin-8 (TSPAN8) is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR.
References:
1. Schmidt, F. et al. (2016) Biological chemistry. PMID: 27180357
2. Müller, M. et al. (2022) Cells 11. PMID: 36078095
3. Pan, SJ. et al. (2015) International journal of molecular sciences 16, 5363-74. PMID: 25761241
4. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232
5. Min, J. et al. (2023) Cellular and molecular life sciences : CMLS 80, 154. PMID: 37204469
6. Zhu, Y. et al. (2023) Cancers 15. PMID: 37835445
Note: For research use only.