Anti-Human WT1 Antibody (SAA1594)

Description: Anti-Human WT1 Antibody (SAA1594) [SAA1594] (RA12238) is a mouse monoclonal antibody detecting WT1 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: WT1, Wilms tumor protein, WT33
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Wilms tumor protein (WT1) is a ~49 kDa protein. Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation.
References:
1. Hamilton, TB. et al. (1995) Nucleic acids research 23, 277-84. PMID: 7862533
2. Stoll, R. et al. (2007) Journal of molecular biology 372, 1227-45. PMID: 17716689
3. Hashimoto, H. et al. (2014) Genes & development 28, 2304-13. PMID: 25258363
4. Smolen, GA. et al. (2004) Cancer research 64, 7846-51. PMID: 1552019
5. Markus, MA. et al. (2006) Experimental cell research 312, 3379-88. PMID: 16934801
6. Weiss, TC. et al. (2009) Biochemistry 48, 148-55. PMID: 19123921
Note: For research use only.