Anti-Human EPHB2 Antibody (SAA1617)

Description: Anti-Human EPHB2 Antibody (SAA1617) [SAA1617] (RA12261) is a mouse monoclonal antibody detecting EPHB2 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: EPHT3, EPTH3, ERK, Developmentally-regulated Eph-related tyrosine kinase, Tyrosine-protein kinase receptor EPH-3, hEK5, Ephrin type-B receptor 2, Tyrosine-protein kinase TYRO5, EK5, HEK5, EPHB2, ELK-related tyrosine kinase, TYRO5, Renal carcinoma antigen NY-REN-47, EPH tyrosine kinase 3, DRT, EPH-like kinase 5
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Ephrin type-B receptor 2 (EPHB2) is a ~117 kDa protein. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk.
References:
1. Berrou, E. et al. (2018) Blood 132, 2067-2077. PMID: 30213874
Note: For research use only.