Anti-Human RAB10 Antibody (SAA1654)

Description: Anti-Human RAB10 Antibody (SAA1654) [SAA1654] (RA12298) is a mouse monoclonal antibody detecting RAB10 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Ras-related protein Rab-10, RAB10
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Ras-related protein Rab-10 (RAB10) is a ~22 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB10 is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, RAB10 regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response.
References:
1. Hutagalung, AH. et al. (2011) Physiological reviews 91, 119-49. PMID: 21248164
2. Babbey, CM. et al. (2006) Molecular biology of the cell 17, 3156-75. PMID: 16641372
3. English, AR. et al. (2013) Nature cell biology 15, 169-78. PMID: 2326328
4. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148
5. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433
6. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220
Note: For research use only.