Anti-Human STX1A Antibody (SAA1684)

Description: Anti-Human STX1A Antibody (SAA1684) [SAA1684] (RA12328) is a mouse monoclonal antibody detecting STX1A in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: STX1A, STX1, Neuron-specific antigen HPC-1, Syntaxin-1A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Syntaxin-1A (STX1A) is a ~33 kDa protein. Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm.
References:
1. Craig, TJ. et al. (2015) Scientific reports 5, 17669. PMID: 2663500
2. Rodríguez, F. et al. (2012) The Journal of biological chemistry 287, 43825-39. PMID: 23091057
Note: For research use only.