Anti-Human ACVR1C Antibody (SAA1706)

Description: Anti-Human ACVR1C Antibody (SAA1706) [SAA1706] (RA12350) is a mouse monoclonal antibody detecting ACVR1C in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Activin receptor-like kinase 7, ALK7, ACVR1C, Activin receptor type IC, ALK-7, Activin receptor type-1C, ACTR-IC
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Activin receptor type-1C (ACVR1C) is a ~54 kDa protein. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells.
References:
1. Xu, G. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5523-34. PMID: 15531507
2. Munir, S. et al. (2004) The Journal of biological chemistry 279, 31277-86. PMID: 15150278
Note: For research use only.