Anti-Human MOSPD2 Antibody (SAA1731)

Description: Anti-Human MOSPD2 Antibody (SAA1731) [SAA1731] (RA12375) is a mouse monoclonal antibody detecting MOSPD2 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Motile sperm domain-containing protein 2, MOSPD2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Motile sperm domain-containing protein 2 (MOSPD2) is a ~59 kDa protein. Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
References:
1. Di Mattia, T. et al. (2018) EMBO reports 19. PMID: 29858488
2. Di Mattia, T. et al. (2020) The EMBO journal 39, e104369. PMID: 33124732
3. Zouiouich, M. et al. (2022) The Journal of cell biology 221. PMID: 3538943
4. Mendel, I. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 198, 2125-2132. PMID: 28137892
Note: For research use only.