Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)

Description: Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) [SAA1782] (RA12426) is a mouse monoclonal antibody detecting Presenilin-1 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1.
References:
1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644
2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183
3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 1059399
4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883
5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933
6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784
7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439
8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632
9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383
10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039
Note: For research use only.