Anti-Human PSEN2/Presenilin-2 Antibody (SAA1783)

Description: Anti-Human PSEN2/Presenilin-2 Antibody (SAA1783) [SAA1783] (RA12427) is a mouse monoclonal antibody detecting Presenilin-2 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: PSEN2, PS-2, AD4, PS2, AD3LP, STM2, E5-1, STM-2, Presenilin-2, AD5, PSNL2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
References:
1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236
2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302
3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394
4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189
5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978
6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576
7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369
Note: For research use only.