Anti-Human LTBP1 Antibody (SAA1797)

Description: Anti-Human LTBP1 Antibody (SAA1797) [SAA1797] (RA12441) is a mouse monoclonal antibody detecting LTBP1 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Transforming growth factor beta-1-binding protein 1, Latent-transforming growth factor beta-binding protein 1, LTBP-1, LTBP1, TGF-beta1-BP-1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Latent-transforming growth factor beta-binding protein 1 (LTBP1) is a ~186 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
References:
1. Miyazono, K. et al. (1991) The EMBO journal 10, 1091-101. PMID: 2022183
2. Saharinen, J. et al. (1996) The EMBO journal 15, 245-53. PMID: 861720
3. Gleizes, PE. et al. (1996) The Journal of biological chemistry 271, 29891-6. PMID: 8939931
4. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403
5. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742
Note: For research use only.