Anti-Human CD245/MYO18A Antibody (SAA1816)

Description: Anti-Human CD245/MYO18A Antibody (SAA1816) [SAA1816] (RA12460) is a mouse monoclonal antibody detecting MYO18A in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: CD245, Myosin containing a PDZ domain, MAJN, SP-R210, Surfactant protein receptor SP-R210, MYO18A, MYSPDZ, Unconventional myosin-XVIIIa, KIAA0216, Molecule associated with JAK3 N-terminus
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Unconventional myosin-XVIIIa (CD245/MYO18A) is a ~233 kDa protein. May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages.
References:
1. Dippold, HC. et al. (2009) Cell 139, 337-51. PMID: 19837035
2. Ng, MM. et al. (2013) Molecular biology of the cell 24, 796-808. PMID: 23345592
3. Tan, I. et al. (2008) Cell 135, 123-36. PMID: 1885416
4. Yang, L. et al. (2015) PloS one 10, e0126576. PMID: 25965346
5. Yang, CH. et al. (2005) The Journal of biological chemistry 280, 34447-57. PMID: 16087679
6. Sever-Chroneos, Z. et al. (2011) The Journal of biological chemistry 286, 4854-70. PMID: 21123169
7. De Masson, A. et al. (2016) Oncoimmunology 5, e1127493. PMID: 27467939
Note: For research use only.