Anti-Human Reticulon-4/RTN4/Nogo-A Antibody (SAA1823)

Description: Anti-Human Reticulon-4/RTN4/Nogo-A Antibody (SAA1823) [SAA1823] (RA12467) is a mouse monoclonal antibody detecting Nogo protein in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: RTN-x, Reticulon-4, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NOGO, Nogo protein, Neurite outgrowth inhibitor, NSP, Reticulon-5, KIAA0886, RTN4, Foocen
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Reticulon-4 (RTN4) is a ~129 kDa protein. Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).
References:
1. Yamamoto, Y. et al. (2014) The Biochemical journal 458, 69-79. PMID: 24262037
2. Urade, T. et al. (2014) The Kobe journal of medical sciences 60, E57-65. PMID: 25612671
3. Wang, S. et al. (2016) eLife 5. PMID: 27619977
4. Rämö, O. et al. (2016) Scientific reports 6, 35969. PMID: 27786289
5. Christodoulou, A. et al. (2016) Journal of cell science 129, 1552-65. PMID: 26906412
Note: For research use only.