Anti-Human ST14 Antibody (SAA1839)

Description: Anti-Human ST14 Antibody (SAA1839) [SAA1839] (RA12483) is a mouse monoclonal antibody detecting ST14 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Tumor-associated differentially-expressed gene 15 protein, Matriptase, Membrane-type serine protease 1, SNC19, TADG15, Serine protease 14, MT-SP1, Prostamin, ST14, Serine protease TADG-15, Suppressor of tumorigenicity 14 protein, PRSS14
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Suppressor of tumorigenicity 14 protein (ST14) is a ~94 kDa protein. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Proteolytically cleaves and therefore activates TMPRSS13.
References:
1. Lin, CY. et al. (1999) The Journal of biological chemistry 274, 18231-6. PMID: 10373424
2. Alef, T. et al. (2009) The Journal of investigative dermatology 129, 862-9. PMID: 18843291
3. Murray, AS. et al. (2017) The Journal of biological chemistry 292, 14867-14884. PMID: 28710277
Note: For research use only.