Anti-Human MAGEA6 Antibody (SAA1840)

Description: Anti-Human MAGEA6 Antibody (SAA1840) [SAA1840] (RA12484) is a mouse monoclonal antibody detecting MAGEA6 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: MAGEA6, Cancer/testis antigen 1.6, MAGE6, MAGE3B antigen, MAGE-6 antigen, CT1.6, Melanoma-associated antigen 6
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Melanoma-associated antigen 6 (MAGEA6) is a ~34 kDa protein. Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
References:
1. Yang, B. et al. (2007) Cancer research 67, 9954-62. PMID: 17942928
2. Doyle, JM. et al. (2010) Molecular cell 39, 963-74. PMID: 20864041
3. Ravichandran, R. et al. (2019) EMBO reports 20, e47352. PMID: 31267705
Note: For research use only.