Anti-Human CD71/TFRC Reference Antibody (JST-TFR09)

Description: Anti-Human CD71/TFRC (JST-TFR09) (BS11915) is a research-grade recombinant antibody targeting CD71. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 4mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Transferrinreceptorprotein1,TfR1,T9,Trfr,p90,CD71,TFRC,TfR,sTfR,TR
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: JST-TFR09,JSTTFR09,JSTTFR09
Background: Transferrin receptor protein 1 (CD71/TFRC) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
References:
1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738
2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240
Note: For research use only. Not suitable for clinical or therapeutic use.