Anti-Human DENND1A Antibody (SAA1871)

Description: Anti-Human DENND1A Antibody (SAA1871) [SAA1871] (RA12515) is a mouse monoclonal antibody detecting DENND1A in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: DENN domain-containing protein 1A, Connecdenn, FAM31A, Protein FAM31A, KIAA1608, DENND1A, Connecdenn 1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: DENN domain-containing protein 1A (DENND1A) is a ~110 kDa protein. Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P.
References:
1. Marat, AL. et al. (2010) The Journal of biological chemistry 285, 10627-37. PMID: 20154091
2. Yoshimura, S. et al. (2010) The Journal of cell biology 191, 367-81. PMID: 20937701
Note: For research use only.