Anti-Human NTAN1/PNAd Antibody (SAA1874)

Description: Anti-Human NTAN1/PNAd Antibody (SAA1874) [SAA1874] (RA12518) is a mouse monoclonal antibody detecting NTAN1 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: NTAN1, PNAA, Protein N-terminal asparagine amidohydrolase, Protein NH2-terminal asparagine deamidase, Protein NTN-amidase, Protein N-terminal Asn amidase, Protein N-terminal asparagine amidase, PNAD, Protein NH2-terminal asparagine amidohydrolase
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Protein N-terminal asparagine amidohydrolase (NTAN1/PNAd) is a ~34 kDa protein. N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.
Note: For research use only.