Anti-Human FXYD5/dysadherin Antibody (SAA1878)

Description: Anti-Human FXYD5/dysadherin Antibody (SAA1878) [SAA1878] (RA12522) is a mouse monoclonal antibody detecting Dysadherin in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: FXYD domain-containing ion transport regulator 5, FXYD5, DYSAD, Dysadherin, IWU1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: FXYD domain-containing ion transport regulator 5 (FXYD5/dysadherin) is a ~19 kDa protein. Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
References:
1. Miller, TJ. et al. (2008) American journal of physiology. Lung cellular and molecular physiology 294, L654-64. PMID: 18263667
2. Ino, Y. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 365-70. PMID: 11756660
Note: For research use only.