Anti-Human BPIFA1/LunX Antibody (SAA1910)

Description: Anti-Human BPIFA1/LunX Antibody (SAA1910) [SAA1910] (RA12554) is a mouse monoclonal antibody detecting BPIFA1 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Von Ebner protein Hl, SPLUNC1, Palate lung and nasal epithelium clone protein, PLUNC, SPURT, Lung-specific protein X, Tracheal epithelium-enriched protein, BPI fold-containing family A member 1, BPIFA1, Secretory protein in upper respiratory tracts, Nasopharyngeal carcinoma-related protein, LUNX, Short PLUNC1, NASG
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: BPI fold-containing family A member 1 (BPIFA1/LunX) is a ~26 kDa protein. Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants.
References:
1. Ning, F. et al. (2014) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, 5349-60. PMID: 25223608
2. Sayeed, S. et al. (2013) Infection and immunity 81, 285-91. PMID: 23132494
3. Liu, Y. et al. (2013) The American journal of pathology 182, 1519-31. PMID: 23499554
4. Walton, WG. et al. (2016) Biochemistry 55, 2979-91. PMID: 27145151
5. Garland, AL. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15973-8. PMID: 24043776
6. Hobbs, CA. et al. (2013) American journal of physiology. Lung cellular and molecular physiology 305, L990-L1001. PMID: 2412419
7. Lindahl, M. et al. (2001) Electrophoresis 22, 1795-800. PMID: 11425234
Note: For research use only.