Anti-Human NME7 Antibody (SAA1925)

Description: Anti-Human NME7 Antibody (SAA1925) [SAA1925] (RA12569) is a mouse monoclonal antibody detecting NME7 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: NME7, Nucleoside diphosphate kinase 7, NDP kinase 7, NDK 7, nm23-H7
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Nucleoside diphosphate kinase 7 (NME7) is a ~42 kDa protein. Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner.
References:
1. Liu, P. et al. (2014) Molecular biology of the cell 25, 2017-25. PMID: 24807905
2. Ren, X. et al. (2022) Cancer research 82, 60-74. PMID: 34764205
3. Yoon, JH. et al. (2005) Biochemistry 44, 15774-86. PMID: 16313181
4. Ji, M. et al. (2025) Life science alliance 8. PMID: 39824631
5. Gui, M. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2207605119. PMID: 36191189
Note: For research use only.