Anti-Human CD264/TNFRSF10D/TRAIL-R4 Antibody (SAA1966)

Description: Anti-Human CD264/TNFRSF10D/TRAIL-R4 Antibody (SAA1966) [SAA1966] (RA12610) is a mouse monoclonal antibody detecting TRAIL-R4 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: TRAIL-R4, TRAIL receptor 4, DcR2, TRAIL receptor with a truncated death domain, TRUNDD, DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TRAILR4, TNFRSF10D, Tumor necrosis factor receptor superfamily member 10D, CD264
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Tumor necrosis factor receptor superfamily member 10D (CD264/TNFRSF10D) is a ~41 kDa protein. Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
References:
1. Degli-Esposti, MA. et al. (1997) Immunity 7, 813-20. PMID: 9430226
2. Pan, G. et al. (1998) FEBS letters 424, 41-5. PMID: 9537512
3. Marsters, SA. et al. (1997) Current biology : CB 7, 1003-6. PMID: 9382840
Note: For research use only.