Anti-Human SLC4A7 Antibody (SAA1974)

Description: Anti-Human SLC4A7 Antibody (SAA1974) [SAA1974] (RA12618) is a mouse monoclonal antibody detecting SLC4A7 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: VHH-mFc
Species reactivity: Human
Form: Liquid
Storage buffer: 30 mM histidine pH 5.8, 10% sucrose, 0.02% Tween 80
Concentration: 0.44 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Electroneutral Na/HCO(3) cotransporter, Sodium bicarbonate cotransporter 3, NBC3, Sodium bicarbonate cotransporter 2, NBCn1, Solute carrier family 4 member 7, Bicarbonate transporter, SLC4A6, NBC2, SBC2, Sodium bicarbonate cotransporter 2b, NBC2B, BT, SLC4A7
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Sodium bicarbonate cotransporter 3 (SLC4A7) is a ~136 kDa protein. Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells.
References:
1. Pushkin, A. et al. (1999) The Journal of biological chemistry 274, 16569-75. PMID: 10347222
2. Park, M. et al. (2002) The Journal of biological chemistry 277, 50503-9. PMID: 12403779
3. Loiselle, FB. et al. (2003) Molecular membrane biology 20, 307-17. PMID: 14578046
4. Loiselle, FB. et al. (2004) American journal of physiology. Cell physiology 286, C1423-33. PMID: 1473671
5. Sedlyarov, V. et al. (2018) Cell host & microbe 23, 766-774.e5. PMID: 29779931
6. Ali, ES. et al. (2022) Molecular cell 82, 3284-3298.e7. PMID: 35772404
Note: For research use only.