Anti-Human TNFAIP6/TSG-6 Antibody (SAA1977)

Description: Anti-Human TNFAIP6/TSG-6 Antibody (SAA1977) [SAA1977] (RA12621) is a mouse monoclonal antibody detecting TNFAIP6 in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, Tumor necrosis factor alpha-induced protein 6, Hyaluronate-binding protein, TSG6, Tumor necrosis factor-inducible gene 6 protein, TNFAIP6, TSG-6
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Tumor necrosis factor-inducible gene 6 protein (TNFAIP6/TSG-6) is a ~31 kDa protein. Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization.
References:
1. Mahoney, DJ. et al. (2005) The Journal of biological chemistry 280, 27044-55. PMID: 15917224
2. Kuznetsova, SA. et al. (2008) Matrix biology : journal of the International Society for Matrix Biology 27, 201-10. PMID: 18042364
3. Lawrance, W. et al. (2016) The Journal of biological chemistry 291, 8014-30. PMID: 2682346
4. Forteza, R. et al. (2007) American journal of respiratory cell and molecular biology 36, 20-31. PMID: 16873769
5. Sanggaard, KW. et al. (2010) The Journal of biological chemistry 285, 21988-93. PMID: 20463016
6. Briggs, DC. et al. (2015) The Journal of biological chemistry 290, 28708-23. PMID: 2646829
7. Lesley, J. et al. (2004) The Journal of biological chemistry 279, 25745-54. PMID: 15060082
8. Dyer, DP. et al. (2016) The Journal of biological chemistry 291, 12627-12640. PMID: 27044744
9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
Note: For research use only.