Anti-Neisseria meningitidis NadA/Neisseria adhesin A Antibody (G9)

Description: Anti-Neisseria meningitidis NadA/Neisseria adhesin A Antibody (G9) [G9] (RA12672) is a human monoclonal antibody detecting Neisseria adhesin A in DB, ELISA, WB.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Human
Isotype: VHH-hFc
Species reactivity: Neisseria meningitidis serogroup B (strain MC58)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: DB, ELISA, WB
Target: nadA, Neisseria adhesin A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Neisseria adhesin A (NadA) is a ~37 kDa protein. Adheres to and induces bacterial uptake by human epithelial cells (Probable). Upon expression in engineered Y.enterocolitica confers an 11- to 15-fold increase in bacterial adherence and uptake by human epithelial cell lines; part of the uptake is mediated by integrin beta-1 (ITGB1) suggesting it may be a human receptor for NadA. A bacterial cell surface protein; antisera against this protein induce complement-mediated killing of this and other strains.
References:
1. Nägele, V. et al. (2011) The Journal of biological chemistry 286, 20536-46. PMID: 21471204
2. Comanducci, M. et al. (2002) The Journal of experimental medicine 195, 1445-54. PMID: 12045242
Note: For research use only.