Anti-Human IL13 Antibody (SAA2016)

Description: Anti-Human IL13 Antibody (SAA2016) [SAA2016] (RA12802) is a human monoclonal antibody detecting IL13 in ELISA, WB. Suitable for Human.
Host species: Human
Isotype: IgG4, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, WB
Target: IL13, NC30, Interleukin-13, IL-13
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Interleukin-13 (IL13) is a ~15 kDa protein. Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells. Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1. Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B.
References:
1. Minty, A. et al. (1993) Nature 362, 248-50. PMID: 8096327
2. McKenzie, AN. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 3735-9. PMID: 8097324
3. Defrance, T. et al. (1994) The Journal of experimental medicine 179, 135-43. PMID: 790368
4. Luttmann, W. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 157, 1678-83. PMID: 8759755
5. Schnyder, B. et al. (1996) Blood 87, 4286-95. PMID: 8639787
6. Miloux, B. et al. (1997) FEBS letters 401, 163-6. PMID: 9013879
7. Kasaian, MT. et al. (2011) Journal of immunology (Baltimore, Md. : 1950) 187, 561-9. PMID: 21622864
Note: For research use only.