Anti-Human PLA2G1B/PLA2 Reference Antibody (DIACC 1010)
- Catalog number: BS12023
- Availability: In Stock
$326.00
- Ex Tax: $326.00
Description: Anti-Human PLA2G1B/PLA2 (DIACC 1010) (BS12023) is a research-grade recombinant antibody targeting Phospholipase A2. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: PhospholipaseA2,PLA2G1B,GroupIBphospholipaseA2,PLA2A,PPLA2,Phosphatidylcholine2-acylhydrolase1B,PLA2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: DIACC-1010,DIACC1010,DIACC1010
Background: Phospholipase A2 (PLA2G1B/PLA2) is a ~16 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner.
References:
1. Suzuki, N. et al. (2000) The Journal of biological chemistry 275, 5785-93. PMID: 10681567
2. Kanda, A. et al. (1992) Biochimica et biophysica acta 1171, 1-10. PMID: 1420353
3. Yu, BZ. et al. (2007) Biochimica et biophysica acta 1768, 2478-90. PMID: 17603006
4. Pan, Y. et al. (2014) Scientific reports 4, 6660. PMID: 25335547
5. Ancian, P. et al. (1995) The Journal of biological chemistry 270, 8963-70. PMID: 7721806
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: PhospholipaseA2,PLA2G1B,GroupIBphospholipaseA2,PLA2A,PPLA2,Phosphatidylcholine2-acylhydrolase1B,PLA2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: DIACC-1010,DIACC1010,DIACC1010
Background: Phospholipase A2 (PLA2G1B/PLA2) is a ~16 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner.
References:
1. Suzuki, N. et al. (2000) The Journal of biological chemistry 275, 5785-93. PMID: 10681567
2. Kanda, A. et al. (1992) Biochimica et biophysica acta 1171, 1-10. PMID: 1420353
3. Yu, BZ. et al. (2007) Biochimica et biophysica acta 1768, 2478-90. PMID: 17603006
4. Pan, Y. et al. (2014) Scientific reports 4, 6660. PMID: 25335547
5. Ancian, P. et al. (1995) The Journal of biological chemistry 270, 8963-70. PMID: 7721806
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human PLA2G1B/PLA2 (DIACC 1010)
