Anti-Human CD18/ITGB2 Reference Antibody (YFC51.1)
- Catalog number: BS12047
- Availability: In Stock
$326.00
- Ex Tax: $326.00
Description: Anti-Human CD18/ITGB2 (YFC51.1) (BS12047) is a research-grade recombinant antibody targeting CD18. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG1-kappaslience
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: ComplementreceptorC3subunitbeta,CellsurfaceadhesionglycoproteinsLFA-1/CR3/p150,95subunitbeta,Integrinbeta-2,MFI7,CD18,ITGB2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Integrin beta-2 (CD18/ITGB2) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.
References:
1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048
2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 2377559
3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629
4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055
5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935
6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714
7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932
8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 1535611
9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992
10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG1-kappaslience
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: ComplementreceptorC3subunitbeta,CellsurfaceadhesionglycoproteinsLFA-1/CR3/p150,95subunitbeta,Integrinbeta-2,MFI7,CD18,ITGB2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Integrin beta-2 (CD18/ITGB2) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.
References:
1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048
2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 2377559
3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629
4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055
5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935
6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714
7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932
8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 1535611
9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992
10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD18/ITGB2 (YFC51.1).
