Anti-Human BRAF/B-Raf (V600E) Antibody (SAA2068)

Description: Anti-Human BRAF/B-Raf (V600E) Antibody (SAA2068) [SAA2068] (RA14047) is a mouse monoclonal antibody detecting BRAF in ELISA. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: BRAF1, RAFB1, Proto-oncogene B-Raf, BRAF, v-Raf murine sarcoma viral oncogene homolog B1, p94, Serine/threonine-protein kinase B-raf
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Serine/threonine-protein kinase B-raf (BRAF) is a ~84 kDa protein. Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2. May play a role in the postsynaptic responses of hippocampal neurons.
References:
1. Brennan, DF. et al. (2011) Nature 472, 366-9. PMID: 2144191
2. Lavoie, H. et al. (2018) Nature 554, 549-553. PMID: 29433126
3. McGrail, K. et al. (2022) Nature communications 13, 7113. PMID: 36402789
4. Stephens, RM. et al. (1992) Molecular and cellular biology 12, 3733-42. PMID: 1508179
Note: For research use only.