Research Grade Nexviazyme/Avalglucosidase alfa
- Catalog number: BS12074
- Availability: In Stock
$424.00
- Ex Tax: $424.00
Description: Nexviazyme/Avalglucosidase alfa (BS12074) is a research-grade recombinant antibody targeting GAA. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species:
Isotype:
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: GAA,Lysosomalalpha-glucosidase,Acidmaltase,Aglucosidasealfa
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: GZ-402666,avalglucosidasealfa-ngpt
Background: Lysosomal alpha-glucosidase (GAA/Aglucosidase alfa) is a ~105 kDa protein. Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
References:
1. Hermans, MM. et al. (2004) Human mutation 23, 47-56. PMID: 14695532
2. Pittis, MG. et al. (2008) Human mutation 29, E27-36. PMID: 18429042
3. Hermans, MM. et al. (1991) The Journal of biological chemistry 266, 13507-12. PMID: 1856189
4. Boerkoel, CF. et al. (1995) American journal of human genetics 56, 887-97. PMID: 771740
5. Roig-Zamboni, V. et al. (2017) Nature communications 8, 1111. PMID: 29061980
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species:
Isotype:
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: GAA,Lysosomalalpha-glucosidase,Acidmaltase,Aglucosidasealfa
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: GZ-402666,avalglucosidasealfa-ngpt
Background: Lysosomal alpha-glucosidase (GAA/Aglucosidase alfa) is a ~105 kDa protein. Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
References:
1. Hermans, MM. et al. (2004) Human mutation 23, 47-56. PMID: 14695532
2. Pittis, MG. et al. (2008) Human mutation 29, E27-36. PMID: 18429042
3. Hermans, MM. et al. (1991) The Journal of biological chemistry 266, 13507-12. PMID: 1856189
4. Boerkoel, CF. et al. (1995) American journal of human genetics 56, 887-97. PMID: 771740
5. Roig-Zamboni, V. et al. (2017) Nature communications 8, 1111. PMID: 29061980
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Nexviazyme/Avalglucosidase alfa.
