Anti-Human ZFYVE20 Antibody (C18)

Description: Anti-Human ZFYVE20 Antibody (C18) [C18] (RA14084) is a mouse monoclonal antibody detecting ZFYVE20 in ELISA, IF, IP. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF, IP
Target: RBSN, ZFYVE20, Rabenosyn-5, 110 kDa protein, FYVE finger-containing Rab5 effector protein rabenosyn-5, RAB effector RBSN, Zinc finger FYVE domain-containing protein 20
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Rabenosyn-5 (RBSN) is a ~88 kDa protein. Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).
References:
1. Nielsen, E. et al. (2000) The Journal of cell biology 151, 601-12. PMID: 11062261
2. de Renzis, S. et al. (2002) Nature cell biology 4, 124-33. PMID: 11788822
3. Naslavsky, N. et al. (2004) Molecular biology of the cell 15, 2410-22. PMID: 15020713
4. Navaroli, DM. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, E471-80. PMID: 22308388
Note: For research use only.